Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs

In general, mammalian Ras guanine nucleotide exchange factors (RasGEFs) show little substrate specificity, although they are often thought to regulate specific pathways. Here, we provide in vitro and in vivo evidence that two RasGEFs can each act on specific Ras proteins. During Dictyostelium develo...

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Sonraí Bibleagrafaíochta
Main Authors: Kae, Helmut, Kortholt, Arjan, Rehmann, Holger, Insall, Robert H, Van Haastert, Peter J M, Spiegelman, George B, Weeks, Gerald
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2007
Ábhair:
Scientific Report
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866193/
https://ncbi.nlm.nih.gov/pubmed/17380187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400936
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