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Inhibition of Cellular 2′-5′ Oligoadenylate Synthetase by the Herpes Simplex Virus Type 1 Us11 Protein

Among the many host genes induced by virus infection and interferon, the eIF2α protein kinase PKR and the 2′-5′ oligoadenylate synthetase (OAS) are both activated by double-stranded RNA (dsRNA) produced in virus-infected cells. Furthermore, each is a critical component that independently acts to inh...

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Bibliografiske detaljer
Main Authors: Sànchez, Ricardo, Mohr, Ian
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866071/
https://ncbi.nlm.nih.gov/pubmed/17229694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02520-06
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