Inhibition of PKR Activation by the Proline-Rich RNA Binding Domain of the Herpes Simplex Virus Type 1 Us11 Protein

Upon activation by double-stranded RNA in virus-infected cells, the cellular PKR kinase phosphorylates the translation initiation factor eukaryotic initiation factor 2 (eIF2) and thereby inhibits protein synthesis. The γ34.5 and Us11 gene products encoded by herpes simplex virus type 1 (HSV-1) are d...

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Publicat a:	J Virol
Autors principals:	Poppers, Jeremy, Mulvey, Matthew, Khoo, David, Mohr, Ian
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 2000
Matèries:	Virus-Cell Interactions
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC113216/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11070019/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.23.11215-11221.2000
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