Inhibition of PKR Activation by the Proline-Rich RNA Binding Domain of the Herpes Simplex Virus Type 1 Us11 Protein

Upon activation by double-stranded RNA in virus-infected cells, the cellular PKR kinase phosphorylates the translation initiation factor eukaryotic initiation factor 2 (eIF2) and thereby inhibits protein synthesis. The γ34.5 and Us11 gene products encoded by herpes simplex virus type 1 (HSV-1) are d...

Full description

Saved in:
Bibliographic Details
Main Authors: Poppers, Jeremy, Mulvey, Matthew, Khoo, David, Mohr, Ian
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC113216/
https://ncbi.nlm.nih.gov/pubmed/11070019
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items