The Antiviral Efficacy of Simian Immunodeficiency Virus-Specific CD8(+) T Cells Is Unrelated to Epitope Specificity and Is Abrogated by Viral Escape

CD8(+) T lymphocytes appear to play a role in controlling human immunodeficiency virus (HIV) replication, yet routine immunological assays do not measure the antiviral efficacy of these cells. Furthermore, it has been suggested that CD8(+) T cells that recognize epitopes derived from proteins expres...

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Autori principali: Loffredo, John T., Burwitz, Benjamin J., Rakasz, Eva G., Spencer, Sean P., Stephany, Jason J., Giraldo Vela, Juan Pablo, Martin, Sarah R., Reed, Jason, Piaskowski, Shari M., Furlott, Jessica, Weisgrau, Kim L., Rodrigues, Denise S., Soma, Taeko, Napoé, Gnankang, Friedrich, Thomas C., Wilson, Nancy A., Kallas, Esper G., Watkins, David I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2007
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866004/
https://ncbi.nlm.nih.gov/pubmed/17192314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01912-06
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