Upstream AP1- and CREB-Binding Sites Confer High Basal Activity on the Adeno-Associated Virus Type 5 Capsid Gene Promoter

In contrast to the prototype adeno-associated virus type 2 (AAV2), the capsid gene P41 promoter of AAV5, within viral constructs that lack inverted terminal repeat sequences, displays a high basal level of expression in 293 cells in the absence of coinfecting adenovirus. Here we demonstrate that thi...

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Bibliographic Details
Main Authors: Ye, Chaoyang, Pintel, David J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865965/
https://ncbi.nlm.nih.gov/pubmed/17202218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02313-06
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