Phosphoinositide-3 kinase binds to a proline-rich motif in the Na(+),K(+)-ATPase α subunit and regulates its trafficking

Endocytosis of Na(+),K(+)-ATPase molecules in response to G protein-coupled receptor stimulation requires activation of class I(A) phosphoinositide-3 kinase (PI3K-I(A)) in a protein kinase C-dependent manner. In this paper, we report that PI3K-I(A), through its p85α subunit-SH3 domain, binds to a pr...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Yudowski, Guillermo A., Efendiev, Riad, Pedemonte, Carlos H., Katz, Adrian I., Berggren, Per-Olof, Bertorello, Alejandro M.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2000
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18657/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10823893/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.100128297
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