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Phosphoinositide-3 kinase binds to a proline-rich motif in the Na(+),K(+)-ATPase α subunit and regulates its trafficking

Endocytosis of Na(+),K(+)-ATPase molecules in response to G protein-coupled receptor stimulation requires activation of class I(A) phosphoinositide-3 kinase (PI3K-I(A)) in a protein kinase C-dependent manner. In this paper, we report that PI3K-I(A), through its p85α subunit-SH3 domain, binds to a pr...

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Bibliografiske detaljer
Main Authors: Yudowski, Guillermo A., Efendiev, Riad, Pedemonte, Carlos H., Katz, Adrian I., Berggren, Per-Olof, Bertorello, Alejandro M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC18657/
https://ncbi.nlm.nih.gov/pubmed/10823893
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