RelA is Required for IL-1β Stimulation of Matrix Metalloproteinase-1 Expression In Chondrocytes

OBJECTIVE: IL-1β stimulates collagenase-1 (MMP-1) expression in articular chondrocytes, leading to cleavage of type II collagen and irreversible cartilage degradation. The nuclear factor kappa B (NF-κB) pathway is potently activated in IL-1β-stimulated cells and has been implicated as an intermediat...

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Detaylı Bibliyografya
Asıl Yazarlar: Raymond, Lauren, Eck, Sarah, Hays, Ezra, Tomek, Ivan, Kantor, Stephen, Vincenti., Matthew
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2006
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865522/
https://ncbi.nlm.nih.gov/pubmed/17097317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2006.09.011
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