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RelA is Required for IL-1β Stimulation of Matrix Metalloproteinase-1 Expression In Chondrocytes
OBJECTIVE: IL-1β stimulates collagenase-1 (MMP-1) expression in articular chondrocytes, leading to cleavage of type II collagen and irreversible cartilage degradation. The nuclear factor kappa B (NF-κB) pathway is potently activated in IL-1β-stimulated cells and has been implicated as an intermediat...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1865522/ https://ncbi.nlm.nih.gov/pubmed/17097317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2006.09.011 |
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