Erythrophagocytosis by Liver Macrophages (Kupffer Cells) Promotes Oxidative Stress, Inflammation, and Fibrosis in a Rabbit Model of Steatohepatitis : Implications for the Pathogenesis of Human Nonalcoholic Steatohepatitis

Nonalcoholic steatohepatitis (NASH) is a progressive fibrotic disease, the pathogenesis of which has not been fully elucidated. Here, we report a molecular aspect of this disease elucidated using rabbits fed a cholesterol-rich high-fat diet and exhibiting insulin resistance. The liver in this model...

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Detalhes bibliográficos
Main Authors: Otogawa, Kohji, Kinoshita, Kohji, Fujii, Hideki, Sakabe, Masahide, Shiga, Ryoko, Nakatani, Kazuki, Ikeda, Kazuo, Nakajima, Yuji, Ikura, Yoshihiro, Ueda, Makiko, Arakawa, Tetsuo, Hato, Fumihiko, Kawada, Norifumi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2007
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1864892/
https://ncbi.nlm.nih.gov/pubmed/17322381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.060441
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