Aryl Hydrocarbon Receptor-Deficient Mice Develop Heightened Inflammatory Responses to Cigarette Smoke and Endotoxin Associated with Rapid Loss of the Nuclear Factor-κB Component RelB

The transcription factor aryl hydrocarbon receptor (AhR) plays an important role in the response to environmental pollutants. However, its role in normal physiology is unclear. To investigate the role of AhR in acute lung inflammation, control and AhR knockout (KO) mice were exposed to inhaled cigar...

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Main Authors: Thatcher, Thomas H., Maggirwar, Sanjay B., Baglole, Carolyn J., Lakatos, Heather F., Gasiewicz, Thomas A., Phipps, Richard P., Sime, Patricia J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2007
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1864867/
https://ncbi.nlm.nih.gov/pubmed/17322371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.060391
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