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Structure-Based Kinetic Models of Modular Signaling Protein Function: Focus on Shp2
We present here a computational, rule-based model to study the function of the SH2 domain-containing protein tyrosine phosphatase, Shp2, in intracellular signal transduction. The two SH2 domains of Shp2 differentially regulate the enzymatic activity by a well-characterized mechanism, but they also a...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Biophysical Society
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1864834/ https://ncbi.nlm.nih.gov/pubmed/17208977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.093484 |
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