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Deterministic Model of Dermal Wound Invasion Incorporating Receptor-Mediated Signal Transduction and Spatial Gradient Sensing

During dermal wound healing, platelet-derived growth factor (PDGF) serves as both a chemoattractant and mitogen for fibroblasts, potently stimulating their invasion of the fibrin clot over a period of several days. A mathematical model of this process is presented, which accurately accounts for the...

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Bibliographic Details
Main Author: Haugh, Jason M.
Format: Artigo
Language:Inglês
Published: Biophysical Society 2006
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1403196/
https://ncbi.nlm.nih.gov/pubmed/16415056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.077610
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