The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jκ (CSL), the target of the Notch signaling pathway

The RTA protein of the Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is responsible for the switch from latency to lytic replication, a reaction essential for viral spread and KS pathogenesis. RTA is a sequence-specific transcriptional activator, but the diversity of its target sites sugg...

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Bibliographic Details
Main Authors: Liang, Yuying, Chang, Jean, Lynch, Stephen J., Lukac, David M., Ganem, Don
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2002
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC186409/
https://ncbi.nlm.nih.gov/pubmed/12154127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.996502
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