Simultaneous determination of N(7)-alkylguanines in DNA by isotope-dilution LC-tandem MS coupled with automated solid-phase extraction and its application to a small fish model

In the present study, we report the development of a sensitive and selective assay based on LC (liquid chromatography)–MS/MS (tandem MS) to simultaneously measure N7-MeG (N(7)-methylguanine) and N7-EtG (N(7)-ethylguanine) in DNA hydrolysates. With the use of isotope internal standards ((15)N(5)-N7-M...

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Bibliographische Detailangaben
Hauptverfasser: Chao, Mu-Rong, Wang, Chien-Jen, Yen, Cheng-Chieh, Yang, Hsi-Hsien, Lu, Yao-Cheng, Chang, Louis W., Hu, Chiung-Wen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2007
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1863567/
https://ncbi.nlm.nih.gov/pubmed/17134374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061447
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