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Simultaneous determination of N(7)-alkylguanines in DNA by isotope-dilution LC-tandem MS coupled with automated solid-phase extraction and its application to a small fish model
In the present study, we report the development of a sensitive and selective assay based on LC (liquid chromatography)–MS/MS (tandem MS) to simultaneously measure N7-MeG (N(7)-methylguanine) and N7-EtG (N(7)-ethylguanine) in DNA hydrolysates. With the use of isotope internal standards ((15)N(5)-N7-M...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Portland Press Ltd.
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1863567/ https://ncbi.nlm.nih.gov/pubmed/17134374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061447 |
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