FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

Mammalian cells adapt to hypoxic conditions through a transcriptional response pathway mediated by the hypoxia-inducible factor, HIF. HIF transcriptional activity is suppressed under normoxic conditions by hydroxylation of an asparagine residue within its C-terminal transactivation domain, blocking...

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Autors principals: Lando, David, Peet, Daniel J., Gorman, Jeffrey J., Whelan, Dean A., Whitelaw, Murray L., Bruick, Richard K.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2002
Matèries:
Research Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC186346/
https://ncbi.nlm.nih.gov/pubmed/12080085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.991402
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