ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

Expansion of CAG trinucleotide repeats that encode polyglutamine is the underlying cause of at least nine inherited human neurodegenerative disorders, including Huntington's disease and spinocerebellar ataxias. PolyQ fragments accumulate as aggregates in the cytoplasm and/or in the nucleus, and indu...

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Bibliografische Detailangaben

Veröffentlicht in:	Genes Dev
Hauptverfasser:	Nishitoh, Hideki, Matsuzawa, Atsushi, Tobiume, Kei, Saegusa, Kaoru, Takeda, Kohsuke, Inoue, Kiyoshi, Hori, Seiji, Kakizuka, Akira, Ichijo, Hidenori
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Cold Spring Harbor Laboratory Press 2002
Schlagworte:	Research Paper
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC186318/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12050113/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.992302
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