ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

Expansion of CAG trinucleotide repeats that encode polyglutamine is the underlying cause of at least nine inherited human neurodegenerative disorders, including Huntington's disease and spinocerebellar ataxias. PolyQ fragments accumulate as aggregates in the cytoplasm and/or in the nucleus, and indu...

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Dades bibliogràfiques

Publicat a:	Genes Dev
Autors principals:	Nishitoh, Hideki, Matsuzawa, Atsushi, Tobiume, Kei, Saegusa, Kaoru, Takeda, Kohsuke, Inoue, Kiyoshi, Hori, Seiji, Kakizuka, Akira, Ichijo, Hidenori
Format:	Artigo
Idioma:	Inglês
Publicat:	Cold Spring Harbor Laboratory Press 2002
Matèries:	Research Paper
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC186318/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12050113/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.992302
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