ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

Expansion of CAG trinucleotide repeats that encode polyglutamine is the underlying cause of at least nine inherited human neurodegenerative disorders, including Huntington's disease and spinocerebellar ataxias. PolyQ fragments accumulate as aggregates in the cytoplasm and/or in the nucleus, and...

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Detalhes bibliográficos
Main Authors: Nishitoh, Hideki, Matsuzawa, Atsushi, Tobiume, Kei, Saegusa, Kaoru, Takeda, Kohsuke, Inoue, Kiyoshi, Hori, Seiji, Kakizuka, Akira, Ichijo, Hidenori
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2002
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC186318/
https://ncbi.nlm.nih.gov/pubmed/12050113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.992302
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