ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

Expansion of CAG trinucleotide repeats that encode polyglutamine is the underlying cause of at least nine inherited human neurodegenerative disorders, including Huntington's disease and spinocerebellar ataxias. PolyQ fragments accumulate as aggregates in the cytoplasm and/or in the nucleus, and indu...

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Dettagli Bibliografici

Pubblicato in:	Genes Dev
Autori principali:	Nishitoh, Hideki, Matsuzawa, Atsushi, Tobiume, Kei, Saegusa, Kaoru, Takeda, Kohsuke, Inoue, Kiyoshi, Hori, Seiji, Kakizuka, Akira, Ichijo, Hidenori
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 2002
Soggetti:	Research Paper
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC186318/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12050113/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.992302
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