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Overexpression of cyclo‐oxygenase‐2 is an independent predictor of unfavourable outcome in node‐negative breast cancer, but is not associated with protein kinase B (Akt) and mitogen‐activated protein kinase (ERK1/2, p38) activation or with Her‐2/neu signalling pathways
BACKGROUND AND AIM: The production of prostaglandins is regulated by cyclo‐oxygenases (COXs), which also have a role in tumour development and progression in various malignancies, including breast cancer. The mechanisms by which COX‐2 contributes to unfavourable prognosis are still poorly understood...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BMJ Group
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1860412/ https://ncbi.nlm.nih.gov/pubmed/16497869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jcp.2005.030650 |
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