Overexpression of cyclo‐oxygenase‐2 is an independent predictor of unfavourable outcome in node‐negative breast cancer, but is not associated with protein kinase B (Akt) and mitogen‐activated protein kinase (ERK1/2, p38) activation or with Her‐2/neu signalling pathways

BACKGROUND AND AIM: The production of prostaglandins is regulated by cyclo‐oxygenases (COXs), which also have a role in tumour development and progression in various malignancies, including breast cancer. The mechanisms by which COX‐2 contributes to unfavourable prognosis are still poorly understood...

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Detalhes bibliográficos
Main Authors: Schmitz, K J, Callies, R, Wohlschlaeger, J, Kimmig, R, Otterbach, F, Bohr, J, Lee, H‐S, Takeda, A, Schmid, K W
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2006
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1860412/
https://ncbi.nlm.nih.gov/pubmed/16497869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jcp.2005.030650
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