Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARγ
The human retinoic acid receptor (hRAR) is a member of the nuclear receptor superfamily that regulates the transcription of target genes in a ligand-dependent manner. The three hRAR isotypes are targets for retinoids that are used in the treatment of various diseases, including breast cancer and ski...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2000
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18601/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10841540/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.12.6322 |
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