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Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARγ

The human retinoic acid receptor (hRAR) is a member of the nuclear receptor superfamily that regulates the transcription of target genes in a ligand-dependent manner. The three hRAR isotypes are targets for retinoids that are used in the treatment of various diseases, including breast cancer and ski...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Klaholz, Bruno P., Mitschler, André, Belema, Makonen, Zusi, C., Moras, Dino
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18601/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10841540/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.12.6322
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