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Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic

Lantibiotics are ribosomally synthesized peptides that undergo posttranslational modifications to their mature, antimicrobial form. They are characterized by the unique amino acids lanthionine and methyllanthionine, introduced by means of dehydration of Ser/Thr residues followed by reaction of the r...

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Bibliographic Details
Main Authors: McClerren, Amanda L., Cooper, Lisa E., Quan, Chao, Thomas, Paul M., Kelleher, Neil L., van der Donk, Wilfred A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1859917/
https://ncbi.nlm.nih.gov/pubmed/17085596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606088103
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