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Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic

Lantibiotics are ribosomally synthesized peptides that undergo posttranslational modifications to their mature, antimicrobial form. They are characterized by the unique amino acids lanthionine and methyllanthionine, introduced by means of dehydration of Ser/Thr residues followed by reaction of the r...

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Detalles Bibliográficos
Main Authors: McClerren, Amanda L., Cooper, Lisa E., Quan, Chao, Thomas, Paul M., Kelleher, Neil L., van der Donk, Wilfred A.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2006
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1859917/
https://ncbi.nlm.nih.gov/pubmed/17085596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606088103
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