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Dosage-dependent rescue of definitive nephrogenesis by a distant Gata3 enhancer

Human GATA3 haploinsufficiency leads to HDR (hypoparathyroidism, deafness and renal dysplasia) syndrome, demonstrating that the development of a specific subset of organs in which this transcription factor is expressed is exquisitely sensitive to gene dosage. We previously showed that murine GATA-3...

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Detalhes bibliográficos
Main Authors: Hasegawa, Susan L., Moriguchi, Takashi, Rao, Arvind, Kuroha, Takashi, Engel, James Douglas, Lim, Kim-Chew
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1858647/
https://ncbi.nlm.nih.gov/pubmed/17046739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2006.09.030
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