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Dosage-dependent rescue of definitive nephrogenesis by a distant Gata3 enhancer
Human GATA3 haploinsufficiency leads to HDR (hypoparathyroidism, deafness and renal dysplasia) syndrome, demonstrating that the development of a specific subset of organs in which this transcription factor is expressed is exquisitely sensitive to gene dosage. We previously showed that murine GATA-3...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1858647/ https://ncbi.nlm.nih.gov/pubmed/17046739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2006.09.030 |
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