Methylation, a major mechanism of p16/CDKN2 gene inactivation in head and neck squamous carcinoma.

We studied 11 head and neck squamous carcinoma (HNSC) cell lines and 46 primary tumors for p16 gene status by protein, mRNA, and DNA genetic/epigenetic analyses to determine the incidence, the mechanism(s), and the potential biological significance of its inactivation. Of the 11 cell lines, only 1 s...

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Hlavní autoři: El-Naggar, A. K., Lai, S., Clayman, G., Lee, J. K., Luna, M. A., Goepfert, H., Batsakis, J. G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 1997
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1858347/
https://ncbi.nlm.nih.gov/pubmed/9403727
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