Apolipoprotein E deficiency in mice: gene replacement and prevention of atherosclerosis using adenovirus vectors.

Apolipoprotein E (apoE)-deficient mice develop marked hyperlipidemia as well as atherosclerosis and thus are an excellent animal model for evaluating the potential for gene therapy in human genetic dyslipoproteinemias. Recombinant adenovirus containing either human apoE (rAdv.apoE) or the reporter g...

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Hauptverfasser: Kashyap, V S, Santamarina-Fojo, S, Brown, D R, Parrott, C L, Applebaum-Bowden, D, Meyn, S, Talley, G, Paigen, B, Maeda, N, Brewer, H B
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1995
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC185787/
https://ncbi.nlm.nih.gov/pubmed/7657831
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