Hepatic lipase gene therapy in hepatic lipase-deficient mice. Adenovirus-mediated replacement of a lipolytic enzyme to the vascular endothelium.

Hepatic lipase (HL) is an endothelial-bound lipolytic enzyme which functions as a phospholipase as well as a triacylglycerol hydrolase and is necessary for the metabolism of IDL and HDL. To evaluate the feasibility of replacing an enzyme whose in vivo physiologic function depends on its localization...

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Hauptverfasser: Applebaum-Bowden, D, Kobayashi, J, Kashyap, V S, Brown, D R, Berard, A, Meyn, S, Parrott, C, Maeda, N, Shamburek, R, Brewer, H B, Santamarina-Fojo, S
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1996
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC507118/
https://ncbi.nlm.nih.gov/pubmed/8609237
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