Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.

Glycoprotein 330 (gp330) is an endocytic receptor expressed in the renal proximal tubules and some other absorptive epithelia, e.g., in the inner ear. The present study shows that the antifibrinolytic polypeptide, aprotinin, and the nephro- and ototoxic antibiotics, aminoglycosides, and polymyxin B...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Moestrup, S K, Cui, S, Vorum, H, Bregengård, C, Bjørn, S E, Norris, K, Gliemann, J, Christensen, E I
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185763/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7544804/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118176
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