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The immunodominant CD8(+) T cell epitope region of Theiler’s virus in resistant C57BL/6 mice is critical for anti-viral immune responses, viral persistence, and binding to the host cells.
Theiler’s virus infection induces an immune-mediated demyelinating disease, providing a relevant animal model of human multiple sclerosis. VP2(121–130)-specific CD8(+) T cells in resistant H-2(b) mice account for the majority of CNS-infiltrating CD8(+) T cells. To further study the role of the CD8(+...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1857342/ https://ncbi.nlm.nih.gov/pubmed/17095033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2006.09.045 |
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