Identification of a potential general acid/base in the reversible phosphoryl transfer reactions catalyzed by tyrosine recombinases: Flp H305

Flp provides a unique opportunity to apply the tools of chemical biology to phosphoryl transfer reactions. Flp and other tyrosine recombinases catalyze site-specific DNA rearrangements via a phosphotyrosine intermediate, similar to the mechanism of type Ib topoisomerases [1]. Unlike most related enz...

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Bibliographic Details
Main Authors: Whiteson, Katrine L., Chen, Yu, Chopra, Neeraj, Raymond, Amy C., Rice, Phoebe A.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1857323/
https://ncbi.nlm.nih.gov/pubmed/17317566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2007.01.011
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