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Geranylgeranyltransferase I as a target for anti-cancer drugs
Posttranslational modification is critical for the function of the gene products of ras oncogenes, which are frequently mutated in cancer. Ras proteins are modified by farnesyltransferase (FTase), but many related small GTPases that also end in a CAAX motif (where C is cysteine, A is often an alipha...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1857249/ https://ncbi.nlm.nih.gov/pubmed/17476354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32108 |
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