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Tumour necrosis factor α blockade induces an anti‐inflammatory growth hormone signalling pathway in experimental colitis

BACKGROUND: Neutralisation of tumour necrosis factor α (TNFα)restores systemic growth hormone function in patients with Crohn's disease, and induces mucosal healing. Anabolic effects of growth hormone depend on activation of the STAT5 transcription factor. Although it has recently been reported...

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Detalhes bibliográficos
Main Authors: Han, X, Benight, N, Osuntokun, B, Loesch, K, Frank, S J, Denson, L A
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1856672/
https://ncbi.nlm.nih.gov/pubmed/16777921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2006.094490
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