A recombinant anti‐carcinoembryonic antigen immunoreceptor with combined CD3ζ‐CD28 signalling targets T cells from colorectal cancer patients against their tumour cells

BACKGROUND AND AIMS: The prognosis of metastatic colorectal cancer is still poor, raising the need for alternative therapeutic approaches, particularly by manipulating the antitumour immune response. Advanced tumour stages, however, are frequently accompanied by functional T cell defects which may b...

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Detalhes bibliográficos
Main Authors: Hombach, A, Schlimper, C, Sievers, E, Frank, S, Schild, H H, Sauerbruch, T, Schmidt‐Wolf, I G H, Abken, H
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2006
Assuntos:
Colorectal Cancer
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1856300/
https://ncbi.nlm.nih.gov/pubmed/16188919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2005.076208
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