Cross linking to tissue transglutaminase and collagen favours gliadin toxicity in coeliac disease

BACKGROUND AND AIMS: Intestinal inflammation in coeliac disease is driven by the gluten fraction of wheat proteins. Deamidation or cross linking of gluten peptides by tissue transglutaminase (tTG), the coeliac disease autoantigen, creates potent T cell stimulatory peptides. Therefore, our aim was to...

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Autores principales: Dieterich, W, Esslinger, B, Trapp, D, Hahn, E, Huff, T, Seilmeier, W, Wieser, H, Schuppan, D
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Group 2006
Materias:
Coeliac Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1856150/
https://ncbi.nlm.nih.gov/pubmed/16188922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2005.069385
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