Cross linking to tissue transglutaminase and collagen favours gliadin toxicity in coeliac disease

BACKGROUND AND AIMS: Intestinal inflammation in coeliac disease is driven by the gluten fraction of wheat proteins. Deamidation or cross linking of gluten peptides by tissue transglutaminase (tTG), the coeliac disease autoantigen, creates potent T cell stimulatory peptides. Therefore, our aim was to...

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Bibliografiset tiedot
Päätekijät: Dieterich, W, Esslinger, B, Trapp, D, Hahn, E, Huff, T, Seilmeier, W, Wieser, H, Schuppan, D
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BMJ Group 2006
Aiheet:
Coeliac Disease
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1856150/
https://ncbi.nlm.nih.gov/pubmed/16188922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2005.069385
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