A Riboswitch Regulates Expression of the Coenzyme B(12)-Independent Methionine Synthase in Mycobacterium tuberculosis: Implications for Differential Methionine Synthase Function in Strains H37Rv and CDC1551

We observed vitamin B(12)-mediated growth inhibition of Mycobacterium tuberculosis strain CDC1551. The B(12) sensitivity was mapped to a polymorphism in metH, encoding a coenzyme B(12)-dependent methionine synthase. Vitamin B(12)-resistant suppressor mutants of CDC1551 containing mutations in a B(12...

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Autors principals: Warner, Digby F., Savvi, Suzana, Mizrahi, Valerie, Dawes, Stephanie S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2007
Matèries:
Gene Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855906/
https://ncbi.nlm.nih.gov/pubmed/17307844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00040-07
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