High frequency of hypermethylation at the 14-3-3 σ locus leads to gene silencing in breast cancer

Expression of 14-3-3 σ (σ) is induced in response to DNA damage, and causes cells to arrest in G(2). By SAGE (serial analysis of gene expression) analysis, we identified σ as a gene whose expression is 7-fold lower in breast carcinoma cells than in normal breast epithelium. We verified this finding...

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Detalhes bibliográficos
Main Authors: Ferguson, Anne T., Evron, Ella, Umbricht, Christopher B., Pandita, Tej K., Chan, Timothy A., Hermeking, Heiko, Marks, Jeffrey R., Lambers, Anouk R., Futreal, P. Andrew, Stampfer, Martha R., Sukumar, Saraswati
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC18556/
https://ncbi.nlm.nih.gov/pubmed/10811911
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