Compartmental Pharmacokinetic Analysis of Oral Amprenavir with Secondary Peaks

Amprenavir is a protease inhibitor that has been shown to have secondary peaks postulated to be due to enterohepatic recycling. We propose a model to describe the pharmacokinetics of amprenavir which accommodates the secondary peak(s). A total of 82 healthy human immunodeficiency virus (HIV)-seroneg...

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Detalhes bibliográficos
Main Authors: Okusanya, Olanrewaju, Forrest, Alan, DiFrancesco, Robin, Bilic, Sanela, Rosenkranz, Susan, Para, Michael F., Adams, Elizabeth, Yarasheski, Kevin E., Reichman, Richard C., Morse, Gene D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855557/
https://ncbi.nlm.nih.gov/pubmed/17283195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00570-06
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