The Second Extracellular Loop of CCR5 Contains the Dominant Epitopes for Highly Potent Anti-Human Immunodeficiency Virus Monoclonal Antibodies

Six mouse anti-human CCR5 monoclonal antibodies (mAbs) that showed potent antiviral activities were identified from over 26,000 mouse hybridomas. The epitopes for these mAbs were determined by using various CCR5 mutants, including CCR5/CCR2B chimeras. One mAb, ROAb13, was found to bind to a linear e...

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Main Authors: Zhang, Jun, Rao, Eileen, Dioszegi, Marianna, Kondru, Rama, DeRosier, Andre, Chan, Eva, Schwoerer, Stephan, Cammack, Nick, Brandt, Michael, Sankuratri, Surya, Ji, Changhua
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2007
Teme:
Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855447/
https://ncbi.nlm.nih.gov/pubmed/17242138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01302-06
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