Determination of Antibiotic Efficacy against Bacillus anthracis in a Mouse Aerosol Challenge Model

An anthrax spore aerosol infection mouse model was developed as a first test of in vivo efficacy of antibiotics identified as active against Bacillus anthracis. Whole-body, 50% lethal dose (LD(50)) aerosol challenge doses in a range of 1.9 × 10(3) to 3.4 × 10(4) CFU with spores of the fully virulent...

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Detalhes bibliográficos
Main Authors: Heine, Henry S., Bassett, Jennifer, Miller, Lynda, Hartings, Justin M., Ivins, Bruce E., Pitt, M. Louise, Fritz, David, Norris, Sarah L., Byrne, W. Russell
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855446/
https://ncbi.nlm.nih.gov/pubmed/17296745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01050-06
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