Systemic lupus erythematosus-associated defects in the inhibitory receptor FcγRIIb reduce susceptibility to malaria

Polygenic autoimmune diseases, such as systemic lupus erythematosus (SLE), are a significant cause of morbidity and mortality worldwide. In recent years, functionally important genetic polymorphisms conferring susceptibility to SLE have been identified, but the evolutionary pressures driving their r...

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Main Authors: Clatworthy, Menna R., Willcocks, Lisa, Urban, Britta, Langhorne, Jean, Williams, Tom N., Peshu, Norbert, Watkins, Nicholas A., Floto, R. Andres, Smith, Kenneth G. C.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855357/
https://ncbi.nlm.nih.gov/pubmed/17435165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608889104
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