Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway

The nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs harboring premature termination codons (PTCs). Seven genes (smg-1–7, for suppressor with morphological effect on genitalia) that are essential for NMD were originally identified in the nematode Caenorhabditis elegans, and orth...

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Bibliographic Details
Main Authors: Longman, Dasa, Plasterk, Ronald H.A., Johnstone, Iain L., Cáceres, Javier F.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2007
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855233/
https://ncbi.nlm.nih.gov/pubmed/17437990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.417707
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