The modifier of Min 2 (Mom2) locus: Embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression

Inactivation of the APC gene is considered the initiating event in human colorectal cancer. Modifier genes that influence the penetrance of mutations in tumor-suppressor genes hold great potential for preventing the development of cancer. The mechanism by which modifier genes alter adenoma incidence...

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Main Authors: Baran, Amy A., Silverman, Karen A., Zeskand, Joseph, Koratkar, Revati, Palmer, Ashley, McCullen, Kristen, Curran, Walter J., Edmonston, Tina Bocker, Siracusa, Linda D., Buchberg, Arthur M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855180/
https://ncbi.nlm.nih.gov/pubmed/17387143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.6089707
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