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Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury

To explore the role of the kallikrein–kinin system in relation to ischemia/reperfusion injury in the kidney, we generated mice lacking both the bradykinin B1 and B2 receptor genes (B1RB2R-null, Bdkrb1(−/−)/Bdkrb2(−/−)) by deleting the genomic region encoding the two receptors. In 4-month-old mice, b...

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Autores principales: Kakoki, Masao, McGarrah, Robert W., Kim, Hyung-Suk, Smithies, Oliver
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855073/
https://ncbi.nlm.nih.gov/pubmed/17452647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701617104
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