Tricyclic antidepressants block N-methyl-D-aspartate receptors: similarities to the action of zinc.

1. Using the radioligand [3H]-MK801, we have examined drug interactions with the phencyclidine recognition site of the N-methyl-D-aspartate receptor. 2. The tricyclic antidepressants desmethylimipramine and imipramine inhibited [3H]-MK801 binding with IC50 values of 7.4 and 22.5 microM, respectively...

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Bibliographic Details
Main Authors: Reynolds, I. J., Miller, R. J.
Format: Artigo
Language:Inglês
Published: 1988
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1854115/
https://ncbi.nlm.nih.gov/pubmed/2905906
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