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Lactose Permease H(+)-Lactose Symporter: Mechanical Switch or Brownian Ratchet?

Lactose permease structure is deemed consistent with a mechanical switch device for H(+)-coupled symport. Because the crystallography-assigned docking position of thiodigalactoside (TDG) does not make close contact with several amino acids essential for symport; the switch model requires allosteric...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Naftalin, Richard J., Green, Nicholas, Cunningham, Philip
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Biophysical Society 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1853157/
https://ncbi.nlm.nih.gov/pubmed/17325012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.100669
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