Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models

BACKGROUND: Drug-drug interactions resulting from the inhibition of an enzymatic process can have serious implications for clinical drug therapy. Quantification of the drugs internal exposure increase upon administration with an inhibitor requires understanding to avoid the drug reaching toxic thres...

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Bibliographische Detailangaben
Hauptverfasser: Vossen, Michaela, Sevestre, Michael, Niederalt, Christoph, Jang, In-Jin, Willmann, Stefan, Edginton, Andrea N
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2007
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1853074/
https://ncbi.nlm.nih.gov/pubmed/17386084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4682-4-13
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