Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models

Por Vossen, Michaela, Sevestre, Michael, Niederalt, Christoph, Jang, In-Jin, Willmann, Stefan, Edginton, Andrea N
Publicado em 2007

A Computational Systems Biology Software Platform for Multiscale Modeling and Simulation: Integrating Whole-Body Physiology, Disease Biology, and Molecular Reaction Networks

Por Eissing, Thomas, Kuepfer, Lars, Becker, Corina, Block, Michael, Coboeken, Katrin, Gaub, Thomas, Goerlitz, Linus, Jaeger, Juergen, Loosen, Roland, Ludewig, Bernd, Meyer, Michaela, Niederalt, Christoph, Sevestre, Michael, Siegmund, Hans-Ulrich, Solodenko, Juri, Thelen, Kirstin, Telle, Ulrich, Weiss, Wolfgang, Wendl, Thomas, Willmann, Stefan, Lippert, Joerg
Publicado em 2011