Adenomatous Polyposis Coli Gene Mutation Alters Proliferation through its β-Catenin-Regulatory Function in Aggressive Fibromatosis (Desmoid Tumor)

Aggressive fibromatosis is a monoclonal proliferation of spindle (fibroblast-like) cells. A subset of lesions contain somatic truncating adenomatous polyposis coli (APC) gene mutations, and all of the lesions contain an elevated β-catenin protein level. A major function of APC is to regulate β-caten...

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Hlavní autoři: Li, Catherine, Bapat, Bharati, Alman, Benjamin A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 1998
Témata:
Short Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1853030/
https://ncbi.nlm.nih.gov/pubmed/9736021
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